منابع مشابه
Biologically motivated computational modeling of chloroform cytolethality and regenerative cellular proliferation.
Chloroform is a nongenotoxic-cytotoxic carcinogen in rodents. As such, events related to cytotoxicity are the driving force for cancer induction. In this paper we extended an existing physiologically based pharmacokinetic (PBPK) model for chloroform to describe a plausible mechanism linking the hepatic metabolism of chloroform to hepatocellular killing and regenerative proliferation. The key as...
متن کاملApplication of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice.
Physiologically based pharmacokinetic (PBPK) models are tools for interpreting toxicological data and extrapolating observations across species and route of exposure. Chloroform (CHCl(3)) is a chemical for which there are PBPK models available in different species and multiple sites of toxicity. Because chloroform induces toxic effects in the liver and kidneys via production of reactive metabol...
متن کاملEnvironmental chemicals and experimental allergic conjunctivitis.
Correspondence : Mikio MIYATA at the above address. was given 2 days before the challenge, with variousconcentrationsbeingtested. Chloroform as trihalomethane in drinking water was administered for 2 days before the challenge. pDichlorobenzene was inhaled at one of several concentrations for 2 days before the challenge. The animals were sacrificed 30 min after the challenge by exsanguination un...
متن کاملToxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats
Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of 500, 1000, 2000 and 5000 mg/kg of fermented extract of M. paradisiaca. The rats were monitored for behavioral changes, toxicity signs and mortali...
متن کاملEffect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver.
Trihalomethanes (chloroform, bromodichloromethane, chlorodibromomethane, and bromoform) are regulated organic contaminants in chlorinated drinking water. In female B6C3F1 mouse liver, the 4 trihalomethanes have demonstrated carcinogenic activity when administered by oral gavage; however, chloroform was not carcinogenic when administered in drinking water. Female B6C3F1 mice were administered th...
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تاریخ انتشار 2001